Toward coherent anti‐Stokes Raman scattering‐Raman optical activity for reaction monitoring in organocatalysis: Chiral vibrational signatures of the two atropisomers (<i>R</i>)‐ and (<i>S</i>)‐MOM‐BINOL in solution

Abstract Coherent anti‐Stokes Raman scattering‐Raman optical activity (CARS‐ROA) is a coherent version of spontaneous ROA spectroscopy, the latter being well‐established chirally sensitive vibrational spectroscopic technique. A central major advantage heterodyne‐detected CARS‐ROA over drastic reduction acquisition times from several hours to approximately 1 min due high ratio chiral signal relative achiral CARS background. Here, we present first demonstration molecules dissolved in an solvent by using experimental setup built conventional broadband spectrometer. Specifically, two atropisomers (R/S) 2,2′‐Bis(methoxymethoxy)‐1,1′‐binaphthyl, methoxymethyl (MOM) bis‐protected derivative 1,1′‐Bi‐2‐naphthol (BINOL), organic dichloromethane (DCM) were characterized employing ~1 ps, mW pump pulses and ~60 fs, 10 Stokes within 4‐min time. MOM‐BINOL important precursor for synthesis great variety many auxiliaries including binaphthyl phosphoric acids, which are class organocatalysts used asymmetric reactions. Overall, this work step toward kinetic reaction monitoring organocatalysis providing necessary short times.